Nature provides effective solutions, and science helps us use them correctly.
Natural Ingredients
Scientific Approach
Dental Applications
Proven Effectiveness
In modern dentistry, there is a growing interest in natural remedies with proven effectiveness. Among these, aloe vera holds a special place - a plant whose healing properties were known even in ancient civilizations5 . Today, as patients increasingly prefer safe and natural alternatives, the development of dental preparations based on aloe vera becomes particularly relevant.
The key stage in developing such products is selecting the optimal carrier base that not only preserves the beneficial properties of the plant but also ensures its delivery to oral tissues.
Aloe vera has been used for medicinal purposes for over 6,000 years, with ancient Egyptians calling it the "plant of immortality."
Over 65% of dental patients express interest in natural alternatives to conventional treatments when available.
Aloe vera (Aloe barbadensis Miller) contains over 75 biologically active substances, which determines its comprehensive impact on oral health5 . Research has revealed vitamins A, C, E, B group, minerals, enzymes, amino acids, and polysaccharides in its composition5 .
The most important component from a dental perspective is the polysaccharide acemannan, which has immunomodulatory, antiviral, and anti-inflammatory properties5 8 .
Aloe vera gel is effective against pathogens of caries and periodontal diseases, particularly Streptococcus mutans, Candida albicans, and Enterococcus faecalis5 .
The enzyme bradykinase and other components can reduce inflammation of gums and mucous membranes5 .
Aloe vera stimulates tissue regeneration and accelerates the healing of ulcers and damage8 .
Neutralizes free radicals, protecting tissues from damage8 .
Aloe vera contains a diverse range of bioactive compounds that contribute to its therapeutic effects in dentistry.
Creating the "Aloe-Dental" gel requires careful selection of a carrier base that meets a number of critically important requirements. This choice directly affects the bioavailability of active components, duration of therapeutic effect, and convenience of use for patients.
Absence of toxicity and irritant effect on the mucous membrane.
Ability to preserve the biological activity of aloe vera components over time.
Ability to adhere to the surface of gums and teeth, ensuring prolonged contact with affected areas.
Gradual release of active substances to maintain therapeutic concentration.
In the scientific work "Selection of carrier base for 'Aloe-Dental' gel for use in dentistry," researchers conducted a comprehensive study of different carrier bases to ensure optimal bioavailability of active aloe vera components1 .
The experiment included several stages of evaluating the properties of different carrier bases1 :
Several types of gel bases with different properties were selected.
Stability, viscosity, pH, and adhesion ability were studied.
Conducted in vitro on special models.
Testing effectiveness against oral disease pathogens.
Limited tests for tolerability and safety.
The study was conducted considering modern requirements for developing dosage forms for dentistry.
The experiment showed that the optimal carrier base for "Aloe-Dental" gel should combine a polymeric framework for prolonged retention on the mucous membrane and hydrophilic components for better penetration of active substances.
| Carrier Base Type | Stability | Adhesion | Controlled Release | Biocompatibility |
|---|---|---|---|---|
| Hydrogel Base | High | Medium | High | High |
| Polymer Base | Very High | High | Very High | High |
| Lipogel Base | Medium | High | Medium | Medium |
| Disease/Condition | Aloe Vera Effectiveness | Treatment Duration | Evidence Level |
|---|---|---|---|
| Chronic Periodontitis | Significant Improvement | 3 months | High |
| Gingivitis | Moderate Improvement | 4-6 weeks | Medium |
| Aphthous Stomatitis | Significant Improvement | 7-10 days | High |
| Oral Lichen | Moderate Improvement | 6-8 weeks | Medium |
Developing an effective "Aloe-Dental" gel requires the use of special reagents and materials. Here are the main ones:
| Reagent/Material | Function in Research | Application Features |
|---|---|---|
| Stabilized Aloe Vera Gel | Source of biologically active substances | Concentration 35-50% for dental gels2 |
| Polysaccharides (Acemannan) | Main active substance | Responsible for immunomodulatory and antiviral action5 |
| Carboxymethylcellulose | Carrier base | Provides necessary viscosity and adhesion to mucosa |
| Preservatives (Sodium Benzoate) | Prevention of microbial contamination | Used in minimal effective concentrations2 |
| Binding Agents | Stabilization of consistency | Ensure homogeneity of gel structure |
Acemannan, the main polysaccharide in aloe vera, is responsible for many of its therapeutic effects in dentistry, including immunomodulation and tissue regeneration5 .
Research indicates that aloe vera concentrations between 35-50% provide optimal therapeutic effects while maintaining product stability and patient comfort2 .
Research in the field of dental preparations based on aloe vera continues, and scientists see significant potential for expanding their application scope. Recent studies show promise in using aloe vera as an auxiliary agent in endodontic treatment, particularly for pretreatment of root canals before cementing pins3 .
Clinical studies also confirm the effectiveness of aloe vera as an alternative to tetracycline fibers in the treatment of chronic periodontitis, which is especially important for patients who prefer natural remedies4 . This opens new horizons for creating safe and effective dental preparations on a natural basis.
Aloe vera shows promise as an irrigating solution in root canal treatment, offering antibacterial properties without toxicity3 .
Natural alternatives like aloe vera have higher patient acceptance rates compared to conventional chemical treatments.
The work of Imamuzo Matthew Iroko and co-authors regarding the selection of a carrier base for "Aloe-Dental" gel demonstrates the importance of a comprehensive approach to developing dental preparations based on natural ingredients. A properly selected carrier base not only preserves the healing properties of aloe vera but also enhances them, ensuring the delivery of active substances to oral tissues.
The future of dentistry lies in the combination of the best achievements of modern science and the healing possibilities of nature, and aloe vera occupies one of the leading places in this process. Further research in this direction will allow creating a new generation of dental preparations - effective, safe, and accessible to a wide range of patients.