Research Articles
Ensuring Robustness in Receptor Occupancy Assays: A Multi-Operator Validation Framework for Clinical Research
This article provides a comprehensive guide for validating the robustness of Receptor Occupancy (RO) assays across multiple operators.
Ensuring Robust RO Assays: A Complete Guide to Validation, Precision, Accuracy, and Sensitivity in Drug Discovery
This comprehensive guide provides researchers and drug development professionals with a detailed framework for validating Receptor Occupancy (RO) assays.
ADAs in RO Assays: Understanding, Detecting, and Mitigating Interference in Bioanalytical Workflows
This article provides a comprehensive guide for researchers and drug development professionals on the critical challenge of anti-drug antibody (ADA) interference in receptor occupancy (RO) assays.
Maximizing Signal-to-Noise: A Guide to Bright Fluorophore Selection for RO Assays with Low Target Expression
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on selecting optimal fluorophores for Receptor Occupancy (RO) assays, with a focus on challenging low-expression targets.
Beyond False Positives: Building and Applying QSAR Models to Predict Chemical-Assay Interference
This article provides a comprehensive guide for researchers and drug development professionals on Quantitative Structure-Activity Relationship (QSAR) models designed to predict chemical-assay interference.
Predicting ADME in Drug Discovery: A Comprehensive Guide to Modern QSAR Models, Applications, and Best Practices
This article provides a comprehensive overview of Quantitative Structure-Activity Relationship (QSAR) models for predicting Absorption, Distribution, Metabolism, and Excretion (ADME) properties in drug discovery.
Predicting Drug Fate: A Comprehensive Guide to Modern QSAR and QSPR Models for Pharmacokinetic Properties
This article provides a comprehensive overview of Quantitative Structure-Activity Relationship (QSAR) and Quantitative Structure-Property Relationship (QSPR) models as critical tools for predicting the pharmacokinetic (ADME) profiles of drug candidates.
The Prentice Criteria Demystified: A Modern Guide to Validating Surrogate Endpoints in Clinical Trials
This comprehensive guide explores the foundational principles, methodological application, common pitfalls, and contemporary validation frameworks of the Prentice criteria for surrogate biomarker validation.
PSP vs. CS-SINS: A Comparative Guide to Measuring Antibody Non-Specific Interactions for Better Biotherapeutics
This article provides a comprehensive comparison of two key techniques for assessing antibody non-specific interactions (NSI): the dual-membrane Octet®/Biacore-based PSP (Positive-Surface-Potential) assay and the high-throughput CS-SINS (Cross-Interaction Surface Plasmon Resonance...
Mastering PK/PD Study Design: A Comprehensive Guide to Optimizing Clinical Trial Success in Modern Drug Development
This article provides a comprehensive guide to Pharmacokinetic/Pharmacodynamic (PK/PD) study design for researchers and drug development professionals.