Research Articles
A Comprehensive Guide to Organ Bath Experiments: From Foundational Principles to Advanced Applications in Drug Discovery
This article provides a complete guide to the organ bath technique, a cornerstone method in pharmacology and physiology for over a century.
High-Throughput Screening: Modern Methods for Accelerating Drug Discovery from Compound Libraries
This article provides a comprehensive overview of high-throughput screening (HTS) methodologies for profiling compound libraries in modern drug discovery.
BBB Penetration Assessment: Techniques and Strategies for CNS Drug Development
This article provides a comprehensive overview of contemporary techniques for assessing drug penetration across the blood-brain barrier (BBB), a critical challenge in central nervous system (CNS) drug development.
A Comprehensive Protocol for Inducing and Assessing Analgesia in Rodent Models: From Foundational Concepts to Advanced Applications
This article provides a comprehensive guide for researchers and drug development professionals on establishing robust protocols for inducing and assessing analgesia in rodent models.
Patch Clamp Electrophysiology in Ion Channel Drug Discovery: From Gold Standard to High-Throughput Screening
This article provides a comprehensive overview of patch clamp electrophysiology and its pivotal role in modern ion channel drug screening.
In Vivo Microdialysis for Neurotransmitter Analysis: A Comprehensive Guide for Researchers and Drug Developers
This article provides a comprehensive overview of in vivo microdialysis, a minimally invasive sampling technique pivotal for measuring unbound neurotransmitter concentrations in the brain extracellular fluid of awake, freely behaving...
In Vitro Binding Assays for Receptor Affinity: A Comprehensive Guide from Principles to Advanced Applications
This article provides a comprehensive guide to in vitro binding assays for quantifying receptor-ligand interactions, a cornerstone of pharmacology and drug development.
Drug Discovery and Development 2025: From Foundational Principles to AI-Driven Breakthroughs
This article provides a comprehensive overview of the modern drug discovery and development process, tailored for researchers, scientists, and development professionals.
LC-MS/MS Method Development and Validation for Quantifying Drug Concentrations in Human Plasma: A Comprehensive Guide for Clinical and Pharmaceutical Research
This article provides a comprehensive guide to the development, optimization, and validation of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) methods for the precise quantification of drug concentrations in human plasma.
Pharmacogenomics in Personalized Medicine: Integrating Genomic Data to Revolutionize Drug Development and Clinical Practice
This article examines the transformative role of pharmacogenomics in advancing personalized medicine for researchers, scientists, and drug development professionals.